<drug> A group of aminoglycoside antibiotics produced by Micromonospora spp. Members include the closely related gentamicin compounds C1, C2 and C1a, together with gentamicin A. They inhibit protein synthesis on 70S ribosomes by binding to the 23S core protein of the small subunit, that is responsible for binding mRNA. Mode of action similar to that of kanamycin, neomycin, paromomycin, spectinomycin and streptomycin. Active against strains of the bacterium Pseudomonas aeruginosa. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)